The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome / 대한생식의학회지

Objective@#This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). @*Methods@#This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. @*Results@#Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41–1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. @*Conclusion@#HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations.

Resonancia magnética en enfermedad de Ménière

Resumen La enfermedad de Ménière (EM) es una conocida causa de vértigo crónico asociado a múltiples síntomas audiológicos fluctuantes (hipoacusia, tinnitus, plenitud aural). Su fisiopatología no es completamente comprendida, pero se ha relacionado al hidrops endolinfático (HE) como entidad principal. A la fecha, varios estudios electrofisiológicos han intentado posicionarse como pruebas diagnósticas definitivas, pero no lo han logrado, ya sea por dificultad técnica para realizarlos o por resultados inconsistentes en la literatura internacional. Pero cabe destacar que varios hallazgos son altamente sugerentes de enfermedad de Ménière como la presencia de una baja tasa de respuesta asociado al aumento del umbral de esta misma en los VEMPs (vestibular evoked myogenic potentials), tanto oculares como cervicales, o el aumento del cuociente entre el potencial de sumación/potencial de acción en la electrococleografía. A pesar de estas pruebas, hasta el día de hoy, el diagnóstico se sigue realizando en base a criterios clínicos consensuados internacionalmente, dado lo dificultosa que es la visualización directa del HE y falta de compresión de otros mecanismos fisiopatológicos de esta enfermedad. En las últimas décadas, ha habido avances prometedores en la detección de hidrops endolinfático con el uso de resonancia magnética, permitiendo la visualización de los espacios peri y endolinfáticos usando gadolinio como contraste. A su vez, esto ha permitido mejoría de las secuencias imagenológicas usadas, el desarrollo de varias nuevas técnicas de procesamiento de imágenes, conllevando que varias escalas o clasificaciones de HE hayan sido propuestas, las cuales serán revisadas en detalle en este trabajo.

Abstract Ménière's disease (MD) is a known cause of chronic vertigo, with multiple fluctuating audiological symptoms (hearing loss, tinnitus, aural fullness). The pathophysiology is not completely understood but has been attributed to endolymphatic hydrops (EH). There are many electrophysiological tests available, but none of them can be considered as the gold standard, either because of difficult technique or inconsistent results in the literature. Nonetheless, some findings are highly suggestive of MD, like the presence of a low response and high threshold in ocular and cervical VEMPs (vestibular evoked myogenic potentials), or the increased ratio between the amplitudes of summation potential and action potential in the electrocochleography. Despite the availability of these tests, the diagnosis of MD is still made clinically, following the diagnostic criteria establish by international consensus, due to the difficulty to visualize the EH and also the lack of full comprehension of other pathophysiological mechanisms. In the last decades, there have been promising advances in the detection of endolymphatic hydrops with magnetic resonance imaging, allowing the visualization of the perilymphatic and endolymphatic space using gadolinium as a contrast agent. At the same time, the imaging sequences have improved, new techniques for imaging processing have been developed, entailing that various classifications or graduation systems for EH have been proposed, which will be review in detail, in this paper.

Study on some medicinal plants having bioactivity in the treatment of chronic nasal sinustitis

A clinical trial was conducted at HCM city Traditional Medicine Hospital, on 70 patients with chronic sinusitis, chronic rhinititis using trivixomtea. The preparation exerted good effect on sinusitis. The symptoms such as head ache, stuffy has abased obviously, high rate of treatment was reported, X-ray image was improved. There is no considerable side effect